Cholesterol Sulfotransferase of Newborn Mouse Epidermis
نویسندگان
چکیده
منابع مشابه
Oxysterols are substrates for cholesterol sulfotransferase.
Oxysterols constitute a class of cholesterol derivatives that exhibit broad biological effects ranging from cytotoxicity to regulation of nuclear receptors. The role of oxysterols such as 7-ketocholesterol (7-KC) in the development of retinal macular degeneration and atheromatous lesions is of particular interest, but little is known of their metabolic fate. We establish that the steroid/sterol...
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A novel extraction procedure, previously used on the cell walls of dermatophytes, has been applied to the epidermis of newborn rat. A leucine-rich fraction was isolated which contained over 60% of the total epidermal radioactivity from [“Hlleucine in 15 to 20% of the total protein. This fraction was further purified by chromatography in DEAE-cellulose and Sephadex G-200. The protein with the hi...
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BACKGROUND Cholesterol sulfate, the most important sterol sulfate in the human circulation, has emerged as a multifaceted molecule. Among its many demonstrated regulatory actions is its ability to influence blood clotting and fibrinolysis. Additionally, cholesterol sulfate is a constituent of human platelets, where it has been shown to support platelet aggregation. METHODS AND RESULTS We have...
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The clonal organization of chimaeric mouse epidermis was demonstrated by in situ staining of whole-mount preparations using monoclonal antibodies directed against H-2k and H-2b antigens. A striking pattern of transversely oriented stripes or patches was found which extended from mid-dorsum to the flank region. The orientation of these patches indicates a preferred directional expansion of clone...
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Presented at the Twenty-ninth Annual Meeting of the Society for Investigative Dermatology, Inc., June 16—18, 1968, San Francisco, California. * From the Division of Dermatology, Department of Medicine, University of California School of Medicine, San Francisco, California. This study was supported in part by USPHS Research Grant No. CA 06386 from the National Cancer Institute, National Institut...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1984
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12264131